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For much of the past two-plus weeks, many of the federal government's 60 witnesses described the horror when a gunman entered the Tree of Life synagogue in Pittsburgh in 2018 and killed 11 worshippers -- the deadliest attack ever on Jewish people in the United States.

By Brendan Pierson and Disha Raychaudhuri Companies accused of fueling the U.S. opioid crisis have so far paid

LONDON A man appeared in court on Saturday charged with three counts of murder, the BBC reported, following

Russia and Ukraine are vying for support from Africa, which along with the rest of the developing world

One of the scientists whose work pioneered the development of medications such as Ozempic and Wegovy has revealed why life may become “so miserably boring” after two years of using the drug. Ozempic is an FDA-approved medication used for the treatment of type 2 diabetes. It works by mimicking a hormone called glucagon-like peptide 1 (GLP-1), which regulates blood sugar levels and slows down the rate at which food leaves the stomach, often creating the feeling of fullness. These semaglutide injections – sold under the brand names Ozempic and Wegovy – have soared in popularity as many people, including Hollywood celebrities, have used it for weight loss. What’s more, people have also found Ozempic has been effective in curing their addictive habits, like drinking, smoking, shopping, or nail biting. However, because of Ozempic’s increasing popularity, it has led to national shortages of the type 2 diabetes treatment – leaving those who actually need it without. In an interview with Wired, professor Jens Juul Holst – who received the Warren Alpert Foundation Prize in 2021 for his work developing treatments based on the GLP-1 hormone – spoke about the effects of Ozempic, and why he believes many people will stop taking the medication after just a few years. “What happens is that you lose your appetite and also the pleasure of eating, and so I think there’s a price to be paid when you do that,” Holst told Wired. “If you like food, then that pleasure is gone. The craving for food for some people is taken away when they take GLP-1 drugs.” He continued: “That may eventually be a problem, that once you’ve been on this for a year or two, life is so miserably boring that you can’t stand it any longer and you have to go back to your old life.” Holst added that medications like Ozempic and Wegovy have been on the market since 2005, though studies show that these people don’t stay on them for very long. “It’s just like every other drug, they don’t stay on it for many reasons,” he explained. “One of the reasons, as I said, is that once you have tried it and you realise you’ve lost interest in food, then that may be enough.” “We don’t know why people stop taking these drugs, but we know for a fact that they do stop. They do that all over the world.” A 2020 study found that 70 per cent of people who took GLP-1 drugs for type 2 diabetes stopped taking them within two years. However, this could pose a problem for many patients taking semaglutide injections. Research has found that people who stopped taking Ozempic or Wegovy for weight loss experienced weight rebound. A trial published in April 2022 saw participants gain back two thirds of the weight they had lost after 68 weeks of taking semaglutide. As for celebrities who use the once-weekly injection for weight loss, despite not having diabetes or clinical obesity, Hans instead called attention to the “many terrible problems” that those with diabetes have struggled with by not having drugs like Ozempic readily available. “Have you ever visited a diabetes hospital? It’s really deplorable,” he said. “People come in with amputated limbs and compromised cognitive functions and heart problems or they can barely move – they’re miserable and depressed. It’s really serious. There is so much you can improve with a drug that is not only a weight-loss drug but is also an anti-diabetic.” Amidst the popularity of semaglutide injections, the US Food and Drug Administration has issued warnings for consumers not to use off-brand versions of Ozempic or Wegovy, because they may not include the same GLP-1 hormone used in approved medications. Earlier this month, agency officials reported problems with patients using compounded versions of semaglutide – which combines traditional semaglutide with other ingredients. These drugs are not FDA-approved, and the agency does not verify the safety or effectiveness of compounded drugs. Consumers should only use drugs containing semaglutide with a prescription from a licensed health care provider and obtained from a state-licensed pharmacy or other facilities registered with the FDA, the agency said. Read More What is ‘Ozempic face’? Doctors warn about facial ageing side effect of diabetes medications How does Wegovy work? The ‘game changing’ weight loss drug beloved by Hollywood FDA warns against using off-brand versions of Ozempic, Wegovy for weight loss Scientist behind Ozempic says drug can make life ‘so miserably boring’ Pregnant Stassi Schroeder admits she wants to ‘try’ Ozempic after giving birth Doctors warn about ‘Ozempic face’ side effect of medications

Despite the lack of sufficient support in Congress to pass a new assault weapons ban, President Joe Biden on Friday said the US has “reached a tipping point” in the fight to strengthen America’s gun laws, due to the activism of the gun violence prevention movement that has gathered increasing strength in recent years. Mr Biden, who was delivering remarks at the National Safer Communities Summit in Hartford, Connecticut, at the invitation of Senator Chris Murphy and a coalition of gun safety groups including Everytown, Moms Demand Action and Giffords, recounted some of the more than 20 executive actions his administration has taken to stem the tide of mass shootings since he took office. He said those politicians who claim to be concerned about crime should realise that crime can’t be tackled without dealing with gun violence. “It’s a simple proposition,” he said. The president also lamented how since 2020, firearms have been the leading cause of death for children in the United States — more than automobile accidents or cancer. He recalled how the assault weapons ban he wrote into the 1994 crime bill enacted under then-president Bill Clinton cut mass shootings “significantly” only to see their number triple when Mr Clinton’s successor, George W Bush, allowed the ban to expire with the aid of a Republican Congress, allowing military-style rifles and high-capacity magazines to “come back into vogue”. Mr Biden also called for a repeal of the Protection of Lawful Commerce in Arms Act, which immunises gun manufacturers from lawsuits filed by gun violence victims, and for the enactment of universal background checks before anyone can purchase high-powered rifles, many of which are modelled off of those issued to American soldiers, as well as safe storage requirements for such weapons. “The United States of America has the finest fighting force in the history of the world [and] provides … service members with the most lethal weapons on Earth. We also require them to receive significant training before they’re allowed to use them. We require extensive background checks and mental health assessment that before they can … use them [and] require them to lock them up or store the weapon responsibly,” he said. “Every gun owner should be required to have the same requirements held to him or her,” he added. The president also hailed governors who have taken action to strengthen state gun laws, including Connecticut’s Ned Lamont, who recently signed more than 12 separate bills to strengthen his state’s firearm regulations, and praised state governments in Illinois and Washington for passing assault weapon and ghost gun bans, as well as the 21 states that have enacted so-called “red flag” laws to allow courts to temporarily disarm people who are determined to pose a risk to the community by a judge. Though chances of a federal assault weapons ban making it to his desk are slim to none given the composition of Congress, Mr Biden promised the gun safety advocates that he will “never stop fighting”. “We will ban assault weapons in this country … we will hold gun makers liable, we will beat the gun industry,” he said. Read More Fox News producer behind chyron calling Biden a ‘wannabe dictator’ parts ways with network Biden snaps back as reporter asks him about ‘big guy’ controversy Biden, looking to shore up Hispanic support, faces pressure to get 2024 outreach details right

The cost of making a classic Pizza Margherita rose more than twice as fast as overall inflation in

Soldiers are in pursuit of the attackers who are thought to be linked to the Islamic State group.

Forty-five years after an Ohio woman went missing somewhere along the West Coast, her two remaining relatives -- the woman's nieces -- now know what became of their Aunt Dolly.

A 19-year-old from Pickford, Michigan, was arrested by the FBI on Friday for allegedly making antisemitic threats on Instagram.

Chris Christie made millions of dollars in lobbying and consultancy fees in the past six years after leaving

European central bankers’ price stability mission is on a collision course with the goal of combating climate change,