List of All Articles with Tag 'science and tech'

Alcohol addiction ruins millions of lives every year, but scientists may have found a cure for this terrible affliction. A new treatment for alcohol use disorder (AUD) has been trialled in monkeys with impressive results and, if these translate to human trials, the impact could be monumental. A team of neuroscientists and physiologists from across the US tested a new type of gene therapy to see if they could directly target the underlying brain circuitry associated with sustained heavy drinking. As they noted, in the journal Nature Medicine, people suffering from AUD commonly return to alcohol use even if they attempt to quit. This is largely to do with what’s known as mesolimbic dopamine (DA) signalling – meaning how the central nervous system circuit communicates the feelgood neurotransmitter dopamine. A protein called glial-derived neurotrophic factor (GDNF) is key to keeping these neurons in this reward circuitry functioning. However, experts have found that levels of GDNF are reduced in people with AUD during periods of alcohol abstinence, most notably in a region of the brain called the ventral tegmental area (VTA), as IFLScience notes. Therefore, the researchers decided to test whether using gene therapy to deliver more GDNF to the VTA could help reinforce this crucial dopaminergic signalling and prevent patients from suffering an alcoholic relapse. The team of scientists explained how alcohol consumption in non-addicts prompts the release of dopamine, creating a pleasurable buzz feeling, but chronic alcohol use causes the brain to adapt and stop releasing so much dopamine. “So when people are addicted to alcohol, they don’t really feel more pleasure in drinking,” Dr Kathleen Grant, a senior co-author of the study, said in a statement. “It seems that they’re drinking more because they feel a need to maintain an intoxicated state.” For their research, Dr Grant and her colleagues used eight rhesus macaque monkeys, who were exposed to increasing concentrations of alcohol over four 30-day “induction” periods. The monkeys then had free access to alcohol and water for 21 hours a day for six months, during which they developed heavy drinking behaviours. This was then followed by a 12-week abstinence phase, with the GDNF treatment performed four weeks in for half of the subjects. The gene therapy was delivered using a a viral vector containing a copy of the human GDNF gene injected directly into the primate’s VTA, according to IFLScience. And the results were truly jaw-dropping. “Drinking went down to almost zero,” Dr Grant said. “For months on end, these animals would choose to drink water and just avoid drinking alcohol altogether. They decreased their drinking to the point that it was so low we didn’t record a blood-alcohol level.” The most exciting aspect of their findings is the suggestion that gene therapy could offer a permanent solution for people with the most severe cases of AUD. This will be a welcome glimmer of hope to many, given that some 29.5 million people were diagnosed with AUD in the US alone in 2021, according to the National Institute on Alcohol Abuse and Alcoholism. Of these 29.5 million sufferers, almost a million (894,000) were aged between 12 and 17. It’ll likely be some time before we know for sure whether the gene therapy can be rolled out in humans, but it’s an important first step in tackling this devastating disorder. Sign up for our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

A dead “vampire” star is feeding on a nearby companion and expelling cannonballs and its behaviour has left astronomers stunned. The dead star is located around 4,500 light-years away and, until now, has baffled astronomers with its unusual behaviour. It is a rapidly spinning neutron star, otherwise known as a pulsar, that has been given the name PSR J1023+0038, shortened to J1023. It emits radiation from both its poles that occasionally reach Earth and also appears to have two different “settings” of brightness. Initially, the behaviour of J1023 confused experts, but now they believe that the stark difference in brightness levels has to do with the star launching out matter over short spaces of time. Maria Cristina Baglio, leader of the research team and scientist at New York University, Abu Dhabi, said in a statement: “We have witnessed extraordinary cosmic events where enormous amounts of matter, similar to cosmic cannonballs, are launched into space within a very brief time span of tens of seconds from a small, dense celestial object rotating at incredibly high speeds.” In addition to the pulsar emitting matter, over the last 10 years, scientists have witnessed the star pulling material from its companion star. The material it is stealing forms a structure called an accretion disk that forms around the star itself. Since it began feeding, the star has been alternating between between “low” and “high” power modes. During moments of high power, the star shines brightly with a variation of X-rays, ultraviolet and visible light. During low power, it emits radio waves and appears much dimmer. In June 2021, experts witnessed a star shooting out hot, luminous matter that has been compared to a cosmic cannonball as the star continually switched modes. J1023 has fascinated experts, who have been able to explain the way the star behaves by observing it. Despite solving many of its mysteries, the scientists aren’t done with it yet. With the Extremely Large Telescope (ELT) in northern Chile currently under construction, it is hoped that when it is ready, scientists will once more be able to observe the pulsar. Sergio Campana, research co-author and Research Director at the Italian National Institute for Astrophysics Brera Observatory, said: “The ELT will allow us to gain key insights into how the abundance, distribution, dynamics and energetics of the inflowing matter around the pulsar are affected by the mode switching behavior.” Sign up to our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

A group of geologists has recently achieved a breakthrough in identifying potential sites for the formation of diamonds. Diamonds, the hardest naturally occurring material we have found, originate under the extreme conditions of immense pressure and high temperatures deep within the Earth's interior. These precious gems are occasionally pushed to the surface in molten rock formations known as kimberlite. However, there are currently two competing theories regarding what is responsible for this rush of kimberlite which brings diamonds to the surface. In a recent study, these theories were closely examined by a research team. In a piece for The Conversation study author and Associate Professor in Earth Science at the University of Southampton, Thomas Gernon explained: “one proposes that kimberlite magmas exploit the ‘wounds’ created when the Earth’s crust is stretched or when the slabs of solid rock covering the Earth - known as tectonic plates - split up.” “The other theory involves mantle plumes, colossal upwellings of molten rock from the core-mantle boundary, located about 2,900km [1,802] beneath the Earth’s surface.” However, neither of these theories adequately explains how magma manages to find its way through the Earth's crust, or the specific composition of the resulting kimberlite. By employing statistical analysis and machine learning, the team analysed the breakup of continents and its correlation with kimberlite formation. Their findings indicated that the majority of kimberlite volcanoes erupt 20 to 30 million years after tectonic breakup. “It also added a major clue,” Gernon explained. “Kimberlite eruptions tend to gradually migrate from the continental edges to the interiors over time at a rate that is uniform across the continents.” Delving deeper into their investigation through computer-generated models, the team ultimately concluded that diamond eruptions stem from a "domino effect." As continents gradually drift apart from each other, they generate rifts of thinned crust. As this happens, regions of thick, cold rock descend into the hot magma beneath, inducing an upsurge of the mantle, which in turn triggers a similar flow in nearby continents. Gernon elaborated on the team's findings, saying, "Various other results from our computer models then advance to show that this process can bring together the necessary ingredients in the right amounts to trigger just enough melting to generate gas-rich kimberlites,” Gernon explained. “Once formed, and with great buoyancy provided by carbon dioxide and water, the magma can rise rapidly to the surface carrying its precious cargo.” Moreover, the same methodology could potentially be employed to locate diamonds and other rare elements. “The processes triggering the eruptions that bring diamonds to the surface appear to be highly systematic,” Gernon siad. “They start on the edges of continents and migrate towards the interior at a relatively uniform rate.” The study is published in the journal Nature. Sign up to our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Chimpanzees are our closest relatives, so it’s not surprising that they can do many of the things that we can. They’re able to create tools and can even use sign language, plus they share 98.8 per cent of their DNA with humans. It is, therefore, no wonder that the question has often been asked: could humans and chimps ever produce offspring? The answer, according to one evolutionary psychologist, is yes – and it’s already happened. Gordum Gallup made the eyebrow-raising claims in an interview with The Sun Online back in 2018. He told the news site that a human-chimpanzee hybrid – which he dubbed a “humanzee” – was born in a Florida lab 100 years ago. And if you’re wondering how the scientists behind the experiment managed to keep it hushed up for decades, it’s because – according to Gallup – they swiftly killed the infant when they realised the implications of what they’d done. Gallup, a professor at New York’s University at Albany, said his former university teacher told him that the secret birth took place at a research facility in Orange Park, where he used to work. “They inseminated a female chimpanzee with human semen from an undisclosed donor and claimed not only that pregnancy occurred but the pregnancy went full term and resulted in a live birth,” the psychologist told The Sun. “But in a matter of days, or a few weeks, they began to consider the moral and ethical considerations and the infant was euthanised.” Putting Gallup’s unsubstantiated story to one side, it’s unclear whether a human-chimpanzee hybrid is even possible. Some experts believe that our human ancestors and chimpanzees may have been capable of interbreeding as late as 4 million years ago according to IFL Science, which notes that our last common ancestor lived 6-7 million years ago. However, the website also notes that this theory is widely contested. It also points out that other animals with similar genetic differences to that of humans and chimps, such as horses and zebras, have been able to reproduce. And yet, the offspring are often infertile. Nevertheless, back in the 1970s, plenty of people believed that a chimp called Oliver was a human-monkey hybrid thanks to his humanistic walk, intelligence and physical features (he was said to have a smaller, flatter face than his ape peers, according to Historic Mysteries). It wasn't until tests were conducted on Oliver in 1996 that the matter was finally settled: he had 48 chromosomes so was categorically not a humanzee but a regular chimp. Oliver The Humanzee www.youtube.com Still, one certainty is that scientists continue to tread an ethical tightrope when it comes to investigating chimps and their potential to further biomedical research. In 2021, scientists created the first (publicly documented) part-monkey, part-human embryo by growing human stem cells in a macaque monkey. The aim of the work, which was carried out at California’s Salk Institute, was to help create organs for transplants and improve our understanding of human development and disease progression. In 2020, a team of German and Japanese scientists spliced human genes into the brains of marmosets, resulting in the monkey fetuses having larger, more human-like brains, according to the study, which was published in the journal Science. Once the experiment was complete, the team destroyed their creations “in light of potentially unforeseeable consequences with regard to postnatal brain function”. One thing’s for sure, no scientist wants to find themselves the architect of a real-life Planet of the Apes. Sign up for our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

We don’t want to alarm anyone, but the sun is broken. A section of the sun has left the surface and begun circulating around the top of the star as if it were a huge polar vortex, and it’s not exactly clear why it’s happened. The observation was made possible thanks to the James Webb Space Telescope, and its no surprise that it piqued the interests of scientists everywhere. Tamitha Skov is a space weather physicist who regularly shares updates on social media, and she seemed incredibly excited about the latest developments. Sign up for our free Indy100 weekly newsletter “Talk about Polar Vortex! Material from a northern prominence just broke away from the main filament & is now circulating in a massive polar vortex around the north pole of our Star,” she wrote. “Implications for understanding the Sun's atmospheric dynamics above 55° here cannot be overstated!” Solar prominences consist of hydrogen and helium, and they extrude from the sun’s service releasing plasma. While there’s confusion around the cause of the phenomenon, it could be related to the reversal of the sun’s magnetic field, as well as the fact that something expected has been known to happen when the sun reaches a 55 degree latitude in every 11-year solar cycle. Solar physicist Scott McIntosh, who is the deputy director at the National Center for Atmospheric Research in Boulder, Colorado told Space.com: "Once every solar cycle, it forms at the 55 degree latitude and it starts to march up to the solar poles. “It's very curious. There is a big 'why' question around it. Why does it only move toward the pole one time and then disappears and then comes back, magically, three or four years later in exactly the same region?" Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Scientists have theorised that if we are going to find life on Mars, it will be microbes and they will be living in caves below the surface. The Perseverance rover, NASA’s exploration robot on the Red Planet, is currently searching for signs of ancient life in the Jezero Crater. Scientists already know that there are so-called lava tubes on Mars, which some think could be large enough to shelter the first human astronauts from the cosmic radiation which is bombarding the planet. When these were formed, they thought conditions on Mars were more similar to those on Earth, with flowing water, an atmosphere and a warmer climate. One theory is that as conditions changed on the surface and Mars lost its magnetic field and atmosphere, life could have shifted underground. Daniel Viúdez-Moreiras from Spain’s National Institute for Aerospace Technology calculated that UV radiation levels would be about 2 percent of the radiation levels found at the surface. Fortunately, we have lava tubes here on Earth too, which could tell us what life could look like in similar conditions elsewhere in the Solar System. Hawai’i’s Mauna Loa volcano lava tubes were recently explored by NASA. Within them, life is sheltered from conditions on the surface. On Earth, that is a bad thing: we have sunlight and oxygen. But on Mars, where conditions are much harsher, that is a big advantage. “The microbes we found in Hawaii could be similar to microbes that once lived on Mars,” researcher Chloe Fishman explained to NASA following a trip to collect samples in April, “or even microbes that live there today.” The team brought back samples from the cave so as to sequence the genomes of the microbes they found there. And there are already plans to explore lava tubes on the Moon, too. So maybe, just maybe, they will hold the secret to life on Mars. Sign up to our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

A worm has been found living inside a woman’s brain, in a horror-movie-style world first. Doctors in Canberra, Australia, were left stunned after they pulled the 8cm (3in) parasite from the patient’s damaged frontal lobe tissue during surgery last year. "Everyone [in] that operating theatre got the shock of their life when [the surgeon] took some forceps to pick up an abnormality and the abnormality turned out to be a wriggling, live 8cm light red worm," said infectious diseases doctor Sanjaya Senanayake, according to the BBC. "Even if you take away the yuck factor, this is a new infection never documented before in a human being." Senanayake and his colleagues believe the parasite could have been in there for up to two months. The patient, a 64-year-old woman from New South Wales, was first admitted to her local hospital in late January 2021 after suffering three weeks of abdominal pain and diarrhoea, followed by a constant dry cough, fever and night sweats, The Guardian reports. By 2022, her symptoms extended to forgetfulness and depression, and she was referred to Canberra Hospital, where an MRI scan of her brain revealed “abnormalities” that required surgery. “The neurosurgeon certainly didn’t go in there thinking they would find a wriggling worm,” Senanayake told the paper. “Neurosurgeons regularly deal with infections in the brain, but this was a once-in-a-career finding. No one was expecting to find that.” The team at the hospital sent the worm to an experienced parasite researcher who identified it as an Ophidascaris robertsi. This type of roundworm is commonly found in carpet pythons – non-venomous snakes that are ubiquitous across much of Australia. Writing in the journal Emerging Infectious Diseases, Mehrab Hossain, a parasitologist, said she suspected that the patient became an "accidental host" to the worm after cooking with foraged plants. The 64-year-old was known to have often collected native grasses from around her lakeside home, Senanayake told The Guardian. He and his co-workers have concluded that the woman was probably infected after a python shed eggs from the parasite via its faeces into the grass. By touching the plants, she may then have transferred the eggs into her own food or kitchen utensils. Fortunately, the unlucky and unique patient is said to be making a good recovery. However, Senanayake told the BBC that her case should serve as an important warning to society more broadly. "It just shows as a human population burgeons, we move closer and encroach on animal habitats. This is an issue we see again and again, whether it's Nipah virus that's gone from wild bats to domestic pigs and then into people, whether its a coronavirus like Sars or Mers that has jumped from bats into possibly a secondary animal and then into humans,” he said. "Even though Covid is now slowly petering away, it is really important for epidemiologists… and governments to make sure they've got good infectious diseases surveillance around." Sign up for our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

For a lot of people, coffee is one of the few things that gets them out of bed and out the door in the mornings. But while it’s tempting to whack the kettle on first thing, a health expert has stated that delaying our first coffee of the day could be much more beneficial to our health. Nutritionist Gabi from The Fast 800 urged people to wait at least 90 minutes before getting their first coffee hit [via the Mirror]. Gabi claims that we can all boost energy levels by doing so. In fact, eating on an empty stomach could even cause your body to enter stress mode and release hormones like adrenaline and cortisol. "Supporting your morning coffee routine with some smart practices can be a game changer for your overall well-being,” Gabi said. She recommends drinking water, as well as eating a meal packed with fibre and protein to balance sugar levels. “Elevated blood sugar can trigger inflammation and set us up to be on a blood sugar roller coaster for the rest of the day, thereby tanking our energy supply,” the health guru said. "Within the first hour of waking, our cortisol levels ideally acutely rise and fall in a response known as our cortisol awakening response. This rise and fall of cortisol represents a healthy nervous system and actually has a big influence on our immune health and even the risk of autoimmune development." She also states that delaying coffee for a minimum of 90 minutes promotes high energy levels. Gabi said: "Morning light exposure is a huge regulator of circadian rhythm and light exposure triggers the healthy release of cortisol in the morning to support the body’s natural rhythm. Getting natural light exposure within the first hour or so of waking is a great way to support optimal hormone balance." It comes after it was revealed that the drink also gives us an extra ‘special boost’ as well as just a caffeine hit. Scientists have claimed that the act of drinking a cup of joe gives the body a lift, making us more alert, which can’t be replicated merely with caffeine. Sign up for our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

A prediction about when society is most likely to collapse, made by scientists in the 1970s, has resurfaced – and it looks pretty bleak. Scientists at the Massachusetts Institute of Technology (MIT) used a computer to model patterns like population, natural resources and energy usage. The study, published by Club of Rome, picked out when these factors could hit “limits to growth”, which they said could lead to the downfall of modern life as we know it. They think we’ve got fewer than two decades left, with collapse due in 2040. Gulp. Sign up to our free Indy100 weekly newsletter At the time, the report wasn’t given much credence. But a similar study was carried out in 2009, and came up with similar results. Published by American Scientist, the more recent study found that the model’s results were “almost exactly on course”. "It is important to recognise that its predictions have not been invalidated and in fact seem quite on target. We are not aware of any model made by economists that is as accurate over such a long time span," the study said. And to make matters worse, Dutch sustainability researcher Gaya Herrington concurred with the prediction in 2021. Speaking to The Guardian, Herrington said: “From a research perspective, I felt a data check of a decades-old model against empirical observations would be an interesting exercise.” Herrington found that data aligned with the predictions made back in 1972, which had a worse case scenario of economic growth coming to halt at the end of this decade, and collapse around 10 years later. Thankfully, there was a reason to be cheerful too. She added: “The key finding of my study is that we still have a choice to align with a scenario that does not end in collapse. "With innovation in business, along with new developments by governments and civil society, continuing to update the model provides another perspective on the challenges and opportunities we have to create a more sustainable world.” Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Deep underground within the Pacific ocean, scientists have made a surprising discovery, which could significantly expand our understanding of marine life. Researchers found an entirely new ecosystem when turning over volcanic crust with the aid of an underwater robot, showing that even now, nature has many more secrets to unearth. The Schmidt Ocean Institute led an expedition with a team of international researchers to investigate a known site in the Pacific, according to Science Alert. Sign up to our free Indy100 weekly newsletter Subsurface fluids were found coursing beneath the ground, while scientists also found an ecosystem of worms, snails and chemosynthetic bacteria. The institute’s executive director, Jyotika Virmani, said: “This truly remarkable discovery of a new ecosystem, hidden beneath another ecosystem, provides fresh evidence that life exists in incredible places.” The new life was found beneath hydrothermal vents, which were first discovered in the 1970s spewing hot fluids loaded with minerals. They were in such a deep, dark location that scientists assumed there would be no life. Ecologist Monika Bright from the University of Vienna said: “Vent animals above and below the surface thrive together in unison, depending on vent fluid from below and oxygen in the seawater from above.” Scientists found tubeworms swimming through volcanic fluids, which makes it easier for them to get around and find new locations. The discovery came on the coast of central America, using a remote-controlled robot 2,500 metres below sea level. Wendy Schmidt, president of the Schmidt Ocean Institute, said: “The discovery of new creatures, landscapes, and now, an entirely new ecosystem underscores just how much we have yet to discover about our Ocean – and how important it is to protect what we don’t yet know or understand.” Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Scientists have discovered an ancient skull in China, like no other they've seen before. The 300,000-year-old child skull was first discovered in Hualongdong back in 2019 alongside other fossil remains. The Chinese Academy of Sciences (CAS) have struggled to match them to a known lineage. The discovery left researchers baffled as it did not resemble Neanderthals or Denisovans, according to Science Alert. It led them to believe we are either missing a branch from the human family tree or need to add to it. While the skull had similarities to early modern humans, there is a lack of chin and was likened to an extinct species of human in Asia known as a Denisovan. This shape has "never been recorded in late Middle Pleistocene hominin fossil assemblages in East Asia," scientists said in a recent analysis. They believe the remains, known in the science world as HDL 6, could possibly be a combination of modern human and unknown hominin that existed in China, according to the outlet. Sign up for our free Indy100 weekly newsletter In other scientific news, archaeologists are too afraid to open the tomb of Qin Shu Huang, who ruled from 221 BC to 210 BC. The tomb is guarded by a terracotta army of soldiers and horses and was found by farmers back in 1974 in the Shaanxi province of China. Not only do archaeologists believe it will cause damage, but there are rumours of deathly booby traps that could kill curious intruders, according to IFL Science. Writings by Chinese historian Sima Qian 100 years after Qin Shu Huang's death claim "Palaces and scenic towers for a hundred officials were constructed and the tomb was filled with rare artifacts and wonderful treasure." He continued: "Craftsmen were ordered to make crossbows and arrows primed to shoot at anyone who enters the tomb. Mercury was used to simulate the hundred rivers, the Yangtze and Yellow River, and the great sea, and set to flow mechanically." Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Nasa’s James Webb telescope’s most recent image of a distant star system has thrown up more questions than answers – literally. The image is of the star system Herbig Haro 46/47, and includes a cosmic object that is shaped like an actual question mark. Scientists think the entity could be a distant galaxy, or two galaxies interacting with one another. One larger galaxy could be distorting the cosmic cloud and gas of the other, for example, forming a shape similar to a question mark. Sign up to our free Indy100 weekly newsletter The red colour of the unusually shaped object in the image suggests it is more distant than the other stars in the picture. “This may be the first time we’ve seen this particular object. Additional follow-up would be required to figure out what it is with any certainty. Webb is showing us many new, distant galaxies – so there’s a lot of new science to be done,” the US’s Space Telescope Science Institute, which manages Webb’s science operations, told Space.com. The star system in the foreground, dubbed Herbig-Haro 46/47, was captured by the Webb telescope’s powerful infrared cameras and consists of two young stars pulled to each other by gravity as they spin. An image reveals the stars as buried deeply, appearing as an orange-white splotch, surrounded by a disk of gas and dust that continued to add to their mass. JWST Finds a Cosmic Question Mark and a Starry Fountain www.youtube.com “Herbig-Haro 46/47 is an important object to study because it is relatively young – only a few thousand years old,” Nasa said in a statement. The pair of actively forming stars have two-sided orange lobes which were created by earlier ejections from these stars. Scientists said the two young stars could give more insight into how stars gather mass over time, given the fact that the process usually takes millions of years. Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.