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(Reuters) -Contract research firm ICON Plc said on Wednesday it is partnering with the U.S. government for a clinical trial

Josh Duhamel and his wife, Audra Mari, are welcome their first child together. The couple, who officially tied the knot in September 2022, shared a joint post to Instagram on 11 September to reveal that they’re expecting. The post included a picture of a baby’s ultrasound, as it was placed next to a white flower on a table. Mari simply captioned the post with: “Baby Duhamel coming soon,” along with a white heart emoji. Many famous faces took to the comments to congratulate the pair, including Duhmael’s ex-wife, Fergie, with whom he shares a 10-year-old son, Axl. “I am truly happy for you guys,” the singer commented. “Axl can’t wait to be a big brother.” “Congratulations! The most beautiful news! I’m thrilled for you both!!” The Girl Next Door star Elisha Cuthbert added. Former Bachelorette star Clare Crawley wrote: “I was just thinking this morning about you!!” Duhamel, 50, and Mari, 29, were first romantically linked in 2019, nearly two years after the actor announced his split from Fergie. In January 2022, the Shotgun Wedding star took to Instagram to reveal that he and Mari were engaged. “It’s on!! She found a message in a bottle that washed ashore and said YES!!” he wrote in the caption, alongside a photo of him and his partner, as she was holding a paper that read: “Audra Diane Mari, Will You Marry Me?” After tying the knot in September 2022, Mari went on to praise her relationship with her now-husband. “Everyone told me that after you get married you feel different,” she told Us Weekly, at the time. “To be honest, I never really believed them and I thought it would feel the same way it’s felt being with Joshua for the last three years. But it’s much different! I feel secure.” Last year, the couple also made headlines when they poked fun at their 21-year age difference. While attending the Casamigos Halloween party in Beverly Hills, California, Mari dressed up as 26-year-old Anna Nicole Smith, while Duhamel dressed up as her 89-year-old husband, billionaire J Howard Marshall. Mari went on to post a video on Instagram of her partner in costume, as he was wearing a bald cap. In the caption, she quipped: “What age difference? Ladies and gentlemen Anna Nicole Smith & J. Howard Marshall.” This wasn’t the first time Duhamel has poked fun at his and his wife’s age gap. During an appearance on The Kelly Clarkson Show in October 2022, he recalled how he had to go to the emergency room for a back injury, mere hours before his wedding. While he said he no longer had the pain during his big day, after going to the doctor, his back issues continued the next day. “The next morning, after the wedding, [I] couldn’t get out of bed again,” Duhamel said. “[My wife’s] like, ‘Oh my God. Everything is fine here. This is, like, the first day of my marriage, and I’m wheeling my husband around in a wheelchair.’ I’m already way older than she is.” “It wasn’t a great start,” he quipped. “But, I was like: ‘Babe, for better or worse.’” Read More Our weekend arts and culture picks, from The Fabelmans to Happy Valley Josh Duhamel and Audra Mari poke fun at their age gap by channeling Anna Nicole Smith and husband for Halloween Jennifer Lopez mysteriously wipes Instagram account and goes dark on other social channels Mom says she was shamed for teaching infant son to take pride in his appearance Kelly Osbourne opens up about weight loss journey Hairspray star reveals she went into labour while attending Beyoncé concert

The US singer-songwriter says his new disability has changed the way he lives and works.

Sepsis is an illness that affects nearly 50 million people worldwide each year, with around 11 million deaths attributed to the condition. In the United States, at least 1.7 million adults in the US develop sepsis annually, and nearly 270,000 die as a result, the Centres for Disease Control and Prevention (CDC) says. It affects 245,000 people in the UK each year, with around 48,000 deaths, according to the UK Sepsis Trust. World Sepsis Day commemorated on 13th September every year, strives to raise global awareness of the life-threatening condition. The day is seen as “an opportunity for people worldwide to unite in the fight against sepsis,” the Global Sepsis Alliance says. Here is everything you need to know about sepsis: What is sepsis? Sepsis Research says when the condition strikes, the immune system “overreacts” and begins to attack the infection and everything else around it “including the body’s own tissues and organs.” “Any type of infection — bacterial, viral or fungal — can lead to sepsis,” it adds. When sepsis occurs, it can cause inflammation and cause blood clotting around the body, if it does not get treated, it can result in death, organ failure and tissue damage, CDC says. Sepsis cannot be caught from another person, the NHS explains. What are the symptoms? The World Health Organisation (WHO) explains that the condition is a “medical emergency,” so if you think a person is exhibiting signs of sepsis or if you are showing signs – make sure you call 999 or go to the emergency room immediately. According to WHO, common signs and symptoms include: • Fever or low temperature and shivering • Confusion • Difficulty breathing • Clammy or sweaty skin • Extreme body pain or discomfort • High heart rate, weak pulse or low blood pressure • Low urine output Symptoms in children include: • Fast breathing • Convulsions • Pale skin • Lethargy • Difficulty waking up • Feeling cold to touch What are the causes? The Mayo Clinic says any type of infection can lead to sepsis and those that more commonly cause the condition include infections of: • Lungs, such as pneumonia • Kidney, bladder and other parts of the urinary system • Digestive system • Bloodstream • Catheter sites • Wounds or burns “Sepsis often presents as the clinical deterioration of common and preventable infections such as those of the respiratory, gastrointestinal and urinary tract, or of wounds and skin. Sepsis is frequently under-diagnosed at an early stage - when it still is potentially reversible,” the Global Sepsis Alliance says. Who is most at risk? The people most at risk of the condition, according to Mayo Clinic, are: • People with lower immune response, such as those being treated for cancer • People with human immunodeficiency virus (HIV). • People with chronic diseases such as diabetes kidney disease or chronic obstructive pulmonary disease (COPD). • people who are in intensive care or longer hospital stays. • People over the age of 65 • Infants How many cases are there globally? The WHO says a scientific publication estimated that in 2017 there were 48.9 million cases and 11 million sepsis-related deaths worldwide, which accounted for almost 20 per cent of all global deaths. That same year, almost half of all global sepsis cases occurred among children with an estimated 20 million cases and 2.9 million global deaths in children under 5 years of age. How can it be prevented? The Global Sepsis Alliance says the best to to avoid sepsis is by preventing infection. This can be done by undergoing vaccinations, ensuring that you only come into contact with clean water, washing your hands properly and if you are giving birth - making sure it is in a clean and sterilised environment. Can sepsis be treated? Sepsis can be treated with appropriate treatment such as antibiotics – this should be given as soon as possible. The CDC says sometimes “surgery is required to remove tissue damaged by the infection”. “Antibiotics are critical tools for treating life-threatening infections, like those that can lead to sepsis,” the CDC adds. Read More 5 things everyone needs to know about eczema 13 potential cancer symptoms you should get checked out How can I improve my teenager’s low mood? Duran Duran’s Andy Taylor says he’s ‘asymptomatic’ after end-of-life diagnosis Nine hours of parallel surgery: how Britain’s first womb transplant was carried out Bursts of activity that make you huff and puff ‘linked to reduced cancer risk’

A mother who felt she was being “eaten away” after hot flushes led to an incurable blood cancer diagnosis in her late 50s has urged women not to ignore symptoms. In the summer of 2022, Barbara Geraghty-Whitehead, 58, a school inclusion manager who lives in Cheshire, began to experience hot flushes, dizziness and she developed an ear infection. She said she “put it to the back of (her) mind”, but her symptoms persisted – and eventually, after months of hesitation, she visited her GP in September 2022 and underwent blood tests. Within a matter of hours, she received a phone call from her doctor, saying that they were concerned about how high her white blood cells were and that they suspected it could be cancer. One week later, after further tests, Geraghty-Whitehead was told she has chronic myeloid leukaemia (CML) and it is incurable. “You say you want to carry on as much as normal, but from that second nothing else was going to be normal anymore,” she told PA Real Life. “I wanted to go in and for them to say, ‘No, it was a mistake, it’s something else,’ but they didn’t, they said it was CML.” Geraghty-Whitehead started taking chemotherapy tablets that same day – and despite experiencing side effects of fatigue, nausea, acid reflux, and a loss of taste, nearly one year later she has responded well to treatment and has been able to see her daughter get married in Cyprus. After nearly ignoring her own symptoms, she wants to encourage others not to “make excuses”, as “people need to know the signs so they can get diagnosed early”. “When I was first diagnosed, you don’t know where to start and that in itself is overwhelming, but the support I’ve received has been fantastic,” Geraghty-Whitehead said. “I think about [my diagnosis] every day and it is hard and I do get upset, but now I’ve just got to face the fact that this is the new me. “I’m never going to be the person that I was before but I’m going to recreate the new me.” Geraghty-Whitehead said she almost ignored her cancer symptoms and attributed her hot flushes to warm weather and “thought no more of it”. She said she did not think it was related to menopause, as she had already been taking hormone replacement therapy (HRT) patches for years to treat her bone pain. “I started not feeling right and I couldn’t figure out what it was, but I didn’t do anything about it – I just left it,” she explained. She added: “I never ever got hot flushes. Even though I was put on HRT patches, it was mainly for my bone pain, so I just put it to the back of my mind and I thought no more of it.” Looking back now, she realises she should have acted sooner – but on September 16, she visited her GP and underwent blood tests. Days later, on the day of the Queen’s funeral, she found herself sat in an empty hospital waiting room, preparing for further blood tests – and by the end of that week, on September 23, Geraghty-Whitehead received the news she has CML and the following minutes felt like “a blur”. “Everything happened so fast, it was just like a roller-coaster,” she said. “I think it was worse waiting for the blood test results because I didn’t know what type of cancer it was, whether I was going to live, whether I was going to die. “But all I wanted was to get the very first tablet into my body, as I felt like I was being eaten away because it was in my blood and your blood travels everywhere.” Geraghty-Whitehead started treatment the same day she was diagnosed, which she said was the “first positive move”. Although she was told her CML is incurable, doctors reassured her other patients had responded well to the chemotherapy tablets she needed to take daily, and this gave her hope. For more information and support, visit Leukaemia Care’s website here: leukaemiacare.org.uk Read More 9 arthritis myths we all need to stop believing What happens at a sexual health check-up? 9 key signs of leukaemia, as awareness is called ‘non-existent’ Cancer-hit dad who planned own funeral outlives three-week prognosis What happens at a sexual health check-up? 9 arthritis myths we all need to stop believing

Many people assume arthritis is just an ‘old person’s’ disease, and an inevitable part of getting older. Try telling that to the parents of toddlers impacted by the condition, or the 20-somethings living with it. The suggestion that it only troubles the elderly is one of many myths associated with arthritis, which affects around 10 million people in the UK. “One in six people live with the pain, fatigue, and disability arthritis can cause. The impact can be huge, affecting the ability to work, care for family, move free from pain and live independently,” says Deborah Alsina, chief executive at the arthritis support charity Versus Arthritis, speaking to mark Rheumatoid Arthritis Awareness Week (September 11–17). “There are many misconceptions when it comes to understanding arthritis, but by shining a light on the reality of living with arthritis day in, day out, we can help grow understanding and inspire people to take action.” Dr Amara Ezeonyeji, consultant rheumatologist from The Lister Hospital in London (part of HCA Healthcare UK), adds: “Arthritis is a general term that refers to a group of over 100 different types of inflammatory joint diseases that affect the musculoskeletal system. The most common symptom of arthritis is joint pain, but it can also cause stiffness, swelling, and decreased joint mobility.” She says the most common form of arthritis is osteoarthritis (OA), often associated with wear and tear of the joints. Other common types are rheumatoid arthritis (RA), an autoimmune disease that primarily affects the joints; psoriatic arthritis, a type of arthritis associated with the skin condition psoriasis; ankylosing spondylitis which primarily affects the spine and can lead to fusion of the vertebrae; and gout, which is caused by the accumulation of uric acid crystals in the joints and often affects the big toe. “There are several myths about arthritis that are often repeated. It’s important to dispel these to promote an accurate understanding of arthritis, and to encourage those affected to seek appropriate medical care and support from a rheumatologist,” Ezeonyeji adds. Here, Alsina and Ezeonyeji debunk nine common arthritis myths… Myth 1: Arthritis only affects the elderly While it is more common in older adults, arthritis can affect people of all ages, including children and young adults. Myth 2: Cracking your knuckles causes arthritisPeople who crack their knuckles will sometimes be wrongly warned that it’ll bring on arthritis, but Ezeonyeji explains: “There’s no scientific evidence linking knuckle cracking to the development of arthritis. When people crack their knuckles, they experience a release of pressure in the joints and relaxation in the surrounding muscles. It can make the joint feel more mobile and is unlikely to cause arthritis or other problems.” Myth 3: It’s just wear and tearAlsina says one of the most damaging myths is that any form of arthritis is just ‘wear and tear’. “Osteoarthritis is the most common type of arthritis and will affect half of us by age 70. But it isn’t an inevitable part of ageing – your joints are not like car tyres destined to wear down and be replaced. They are made of complex living tissue that our bodies constantly repair and maintain, and osteoarthritis occurs when our bodies can no longer do this effectively,” she says. “Our joints get stronger the more we use them, so keeping physically active and maintaining a healthy weight can help keep osteoarthritis under control.” Myth 4: Cold damp weather causes arthritisAlthough cold and damp weather can sometimes make arthritic joints feel worse, it’s definitely not why arthritis starts. Ezeonyeji explains: “Weather can influence joint discomfort, but it doesn’t cause arthritis. Arthritis is primarily a result of genetic and environmental factors.” Myth 5: Exercise makes arthritis worse People with arthritis can often find it hard to maintain regular physical activity, but a lack of movement can actually increase symptoms such as stiffness and pain, warns Alsina. “Building activity into your daily routine can help improve this, because using your joints builds muscle strength and improves the blood supply, all of which can ease symptoms and keep joints in better shape for longer.” She says different activities will suit different people, but adds: “Swimming and cycling are great exercises to try, as they get the body moving without putting pressure on painful joints.” It’s always a good idea to seek advice from a healthcare specialist if you are unsure what types of exercise will be suitable for you. Myth 6: Arthritis is just joint pain – it’s not serious Ezeonyeji says that while arthritis can be debilitating and lead to a reduced quality of life, it can get even more serious than that for some people. “Rheumatoid arthritis, for instance, is an autoimmune disease that can affect various organs and tissues in addition to joints,” she points out. Myth 7: There’s no treatment for arthritis While there’s no cure for arthritis, Ezeonyeji says there are many effective treatments for managing the disease, including pain relief medication, physiotherapy, disease modifying agents and biological drugs for inflammatory arthritis, plus joint surgery in some cases. “It’s also recommended that people with arthritis modify their lifestyle and try to lose weight [if they need to], follow a healthy balanced diet, exercise regularly and stop smoking,” she adds. Myth 8: Miracle cures can make arthritis disappear Although some people with arthritis believe copper or magnetic bracelets ease symptoms, Alsina says studies show no evidence to support this. “It’s the same with lots of supplements, and some of these are really pricey,” she observes. “Interestingly though, placebos can be very effective and continue to work even if you know it’s a placebo, so if you find these helpful there’s no reason to stop.” Myth 9: Certain foods definitely help/hinder arthritisThere are claims that foods like tomatoes can cause arthritis flares, and other foodstuff like cider vinegar may help it. Alsina says: “Sadly there’s no good evidence that there are specific foods you should avoid or have more of. But if you do find things that are helpful or make your symptoms worse, then listen to your body.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Prince Harry spotted at Windsor Castle on anniversary of Queen’s death How the weather can change the way you dream All the times Kate has channelled the late Queen’s style since her death

Kate Garraway has opened up about the realities of caring for her husband, Derek Draper, in a new interview. A former lobbyist, Draper, 55, was left with long-lasting organ damage after falling seriously ill with Covid-19 in March 2020. After spending more than a year in hospital with Covid from March 2020 to April 2021, partly in an induced coma, he has been in and out of hospital since then for various treatments, including in October 2022 after he contracted sepsis. Now, speaking to The Sunday Times, Garraway, 53, has spoken at length about Draper’s condition, the constant care he requires today, and the toll it takes on her. Currently, Draper has no physical mobility and needs to be held upright by two people five times a day in order to bear any weight. “Being upright is incredible for the brain,” Garraway explained. “We’re meant to be upright – you don’t want your brain to adjust to being flat.” However, a lack of progress has taken a toll on them both. “The truth is he’s terribly, terribly depressed,” the Good Morning Britain presenter added. “I think sickness is selfish,” she continued. “Selfish in the sense that it does strip you of your empathy. He does get very emotional about the strain this has put on me. “But when someone’s body doesn’t work, their brain can’t make anything or anyone else a priority.” Garraway went on to speak about how, as his condition progresses, those around her have become increasingly concerned. “My friends worry that I can’t spend my life forever attached to whether Derek is having a good or bad day, for my own sanity,” she said. “So I’ve got to create a bit of headspace. But we’ve never had a period where we could say, ‘Well, at least he’s safe now.’” The interview comes after Garraway was made a Member of the Order of the British Empire (MBE) by the Prince of Wales at Windsor Castle in June. The presenter was recognised in the 2022 New Year Honours for her services to broadcasting, journalism, and charity. Draper was able to attend the investiture ceremony in his wheelchair, wearing a blue suit and stripe tie. Garraway wore a cream dress with a bejewelled collar and a matching headpiece. When it was announced that she had been awarded the accolade, Garraway said on GMB: “I actually feel very awkward about it all really, I don’t know why, because I’m thrilled to bits and incredibly honoured. “But you just sort of think, ‘What? Me?’, and then you think it’s not real.” Read More Kate Garraway’s husband Derek Draper admitted to hospital after MBE ceremony Derek Draper watches as wife Kate Garraway collects MBE from Prince William Susanna Reid shares message on GMB for Kate Garraway and Derek Draper after Elton John tribute Father praised for ‘embarrassing’ dance when picking daughter up from high school What are Blue Zones and how do they impact your health? Hairspray star reveals she went into labour while attending Beyoncé concert

The Western Isles' Linda Norgrove Foundation hopes to get the 20 women to Scotland.

Evidence is mounting that the benefits of play go well beyond entertainment and improved hand-eye coordination.

When Jay "Jeezy" Jenkins was growing up, talking about your feelings could be dangerous. The Grammy-winning hip-hop artist explores how he came to understand and improve his mental health in a new memoir, "Adversity For Sale."

By David Randall NEW YORK U.S. stock investors are turning their focus to next week’s inflation data, which

A father has been praised for the “embarrassing” dance moves he’s performed when picking his daughter up from high school. Jevin Smith shared a video to TikTok last month of some of the “most embarrassing parent pick ups” he’s done at his daughter’s school. Smith’s video started off with him wearing a gold jacket and black pants, while he danced to MC Hammer’s “2 Legit 2 Quit.” While continuing some of his moves, he started making his way towards his daughter, Jayna, who had her head down, seemingly due to her embarrassment over her father’s arrival. As she continued to walk next to her father while they headed towards his car, Smith danced in front of her. He also continued dancing as he walked towards the driver’s seat of the car. Although the next clip of the montage began in a similar fashion, it had a different musical theme, as the text read: “How I would have picked up my daughter in the 80s.” Jayna was seen laughing and shaking her head, as her father was wearing a curly wig with a sweatband over it, a striped tank top, tan shorts, and socks that went up to his knees. The video continued with Smith dancing to “I Feel For You’” by Chaka Khan, before he opened his car door for his daughter. In the background, some of the other students at Jayna’s school were seen laughing and cheering Smith on. Smith’s third video in the montage showed him wearing a curly wig, hat, black sweatshirt, and matching jeans, before making his way towards his daughter, who was was exiting her school. While Jayna was laughing and had her head down, Smith went on to rap along to Ice Cube’s “It Was a Good Day”. He also poked fun at the song’s title in the text on the video, writing: “Today was a good day for me, but was it for my daughter?” As he continued his singing and dancing, he put his arm over his daughter’s shoulder, before taking her school bag from her. He then opened the backseat door of his car for her, while she still appeared embarrassed by her father’s dancing. Smith’s video has quickly gone viral on TikTok, where it has amassed more than four million views. In the comments, many people went on to applaud the father for his dance moves, and made jokes about how he could have entertained some of the other students at the school. @wealthyjev Here’s a #throwback of some of my most #embarrassing #DaddyDaughterPickUp s 😳🤣🚙 I know my daughter @Reigny cant wait yo graduate 🤷🏾♂️ Which #parentpickup was your favorite? 🤔 #throwbackthursday ♬ original sound - Wealthy Jev “I absolutely love that you open the door for her! Great dad!!” one wrote. “This man better have his own page in the yearbook,” another quipped, while a third added: “If I was a teacher at that school, I would be RUNNING after the bell rings to watch this in person.” Speaking to Today, Jayna, who’s a senior in high school, noted that while she was initially embarrassed by her father’s dances, she now finds them to be quite amusing. “In the beginning, when he first started doing it, I was like, this is unbearable. Imagine watching your father get out of the car and start dancing,” Jayna said. “Now I think it’s hilarious. There’s never a time when I’m upset. He’s like a celebrity at school now. Everyone loves his TikTok.” Smith also noted to the publication that, while he started doing these dances for Jayna during her sophomore year, he doesn’t do them all the time. The father, who picks his daughter up from school everyday, acknowledged that he can tell by her face when she’s had a bad day. During those instances, he’ll “either tone down the dance, or get right back in the car,” as reported by Today. He added that he also only does the dances once a month, and doesn’t tell her daughter when it’s going to happen. The Independent has contacted Smith for comment. Read More Lily Allen celebrates third wedding anniversary with David Harbour in sweet Instagram post Elon Musk reveals names of his twins with Shivon Zilis Alabama Barker shares sweet note from ‘best dad’ Travis Barker Alabama Barker shares sweet note from ‘best dad’ Travis Barker Gigi Hadid talks about balancing work and co-parenting with Zayn Malik Seal praises his and Heidi Klum’s daughter Leni for making him ‘a better person’